Structure of the HHARI Catalytic Domain Shows Glimpses of a HECT E3 Ligase
Figure 2
Solution Structure of the HHARI RING2 domain.
(A) Superposition of the 20 lowest energy solution structures of the HHARI RING2 domain (residues 325-396; backbone RMSD 0.6 ± 0.2 Å). (B) Ribbon structure of the HHARI RING2 domain showing helix α1 (N335-A339) and β-strands β1 (T341-C344), β2 (V349-E352), β3 (H359-361), and β4 (E370-C372). Zinc is represented as silver spheres. Side chains of residues involved in Zn2+-coordination and the catalytic cysteine substituted with serine (C357S) are labeled and shown in yellow.