Single Nucleotide Polymorphism Array Profiling of Adrenocortical Tumors - Evidence for an Adenoma Carcinoma Sequence?
Figure 8
Relationship between genomic alterations and clinical outcome in malignant adrenocortical tumors.
A) Unsupervised euclidean distance genomic clustering (complete linkage) in 22 carcinomas. Best cluster obtained including a specific combination of chromosomes (i.e. chr 1, 2, 4, 5, 7, 12, 13, 14, 17, 18, 20, 22, and X).
B) Relationship between the genetic clusters and the clinical parameters: tumor size and Weiss score (Mann-Withney test), ENSAT tumor stage (Fisher’s test) and overall survival (Kaplan-Meyer curve and log-rank test).
In black the patients with a worst prognosis (overall survival < 24 months), in grey the patients with an intermediate prognosis (overall survival 24-48 months), and in white the patients with a good prognosis (overall survival > 48 months or still alive at the last follow up).