Adult Hippocampal Neurogenesis and mRNA Expression are Altered by Perinatal Arsenic Exposure in Mice and Restored by Brief Exposure to Enrichment
Figure 2
Perinatal arsenic exposure does not alter proliferation of NPC at PD35 in male mice.
Representative images of neural progenitor cell (NPC) proliferation at PD35 in the dentate gyrus: (A) Colocalization of Ki67 (endogenous mitotic marker) and BrdU (exogenous S-phase marker) determine the proliferating pool of neural progenitor cells in (B) control and (C) arsenic-exposed animals. (D) There was no significant effect of treatment on the proliferation of neural progenitor cells, n = 7–9 mice per group (each from different litters). Results are expressed as the mean ± SEM. DAPI (blue), BrdU (green), Ki67 (red).