The Majority of Adult Pneumococcal Invasive Infections in Portugal Are Still Potentially Vaccine Preventable in Spite of Significant Declines of Serotypes 1 and 5
Figure 2
Number of isolates expressing serotypes included in conjugate vaccines causing invasive infections in Portugal (2009–2011).
The number of isolates expressing each serotype in each of the age groups considered is indicated. Isolates recovered from patients 18 to 49≥65 yrs are indicated by open circles. Isolates presenting both erythromycin resistance and penicillin non-susceptibility (EPNSP) are represented by closed black bars. Penicillin non-susceptible isolates (PNSP) are indicated by dark hatched bars. Erythromycin resistant pneumococci(ERP) are indicated by light hatched bars. Isolates susceptible to both penicillin and erythromycin are represented by white open bars. The serotypes included in each of the conjugate vaccines are indicated by the arrows. NVT – non-vaccine serotypes, i.e., serotypes not included in any of the currently available vaccines (PCV13 and PPV23). Twenty-eight NVT were detected representing 236 isolates as follows: 6C (n = 36); 23A (n = 20); 12B (n = 19); 16F (n = 18); 23B and 33A (n = 16 each); 15A and 29 (n = 15 each); 24F (n = 13); non-typable (n = 10); 31, 34 and 35F (n = 8 each); 7C, 25A and 35B (n = 5 each); 21 (n = 4); 18A (n = 3); 13 and 17A (n = 2 each); 7A, 11C, 15F, 24A, 25F, 28A, 28F and 37 (n = 1 each).