Low Seroprevalent Species D Adenovirus Vectors as Influenza Vaccines
Figure 1
Comparison of cross-protection by monovalent 2009 H1N1 vaccine (MIV) vs. Ad expressing 2009 H1N1 HA (Ad-TX).
Groups of 5 BALB/c mice were immunized intramuscularly with either the MIV (A) or the Ad-TX vectored vaccine (B) at the indicated vaccine doses and then challenged intranasally with A/PR/8/34. Weight loss and survival was monitored. There were no cross-protective immune responses induced in the MIV immunized mice and all mice were sacrificed due to weight loss by day 7. However, 100% of mice immunized with ≥108 viral particles (75 ng) of Ad-TX had cross-protective immune responses and were completely protected from death.