Spatial Memory and Long-Term Object Recognition Are Impaired by Circadian Arrhythmia and Restored by the GABAAAntagonist Pentylenetetrazole
Figure 1
Representative actograms of a hamster exposed to the DPS protocol.
(A) Locomotor activity before the DPS protocol is plotted horizontally in 10-min bins over 24 h and then double-plotted to facilitate visualization of the rhythms. (B) Activity four weeks after the DPS protocol. Successive days are plotted vertically beginning at day 0. (C) Plots of Lomb-Scargle time series analysis indicate significant periodicity in the circadian range when this animal was entrained. (D) Time series analysis confirmed that the DPS protocol eliminated circadian timing entirely. Peaks above the horizontal line indicate statistically significant periodicity (P<0.05).