Comparative Analyses of Lipoprotein Lipase, Hepatic Lipase, and Endothelial Lipase, and Their Binding Properties with Known Inhibitors
Figure 10
Binding modes and interactions of LPL with its inhibitors, CHEMBL339297 and CHEMBL485946.
The pictures on the left side are of LPL complexed with (a) CHEMBL339297, and (c) CHEMBL485946. The protein surface and binding pocket is colored, with blue representing the positively charged region, red representing the negatively charged region, green representing the hydrophobic region, and gray representing the protein backbone. The pictures on the right side were created by LigPlot+ [48] for the representation of the interactions with (b) CHEMBL339297 and (d) CHEMBL485946, showing the inhibitors (purple), residues involved in hydrogen bonding with the ligand (brown), along with their hydrogen bonds (green), and residues involved in non-bonded interactions (red spikes).