A Human Antibody to the CD4 Binding Site of gp120 Capable of Highly Potent but Sporadic Cross Clade Neutralization of Primary HIV-1
Figure 11
Amino acid alignment of the 1F7 (A) heavy chain and (B) light chain variable regions along with several other CD4bs antibodies. The 1F7 germline (gl) is shown in blue and residues that differ between 1F7 and its germline sequence are underlined. (A) Antibody F105 and 1F7 share the same variable heavy chain germline family IGHV4-59*01. However, the 1F7 heavy chain sequence is less conserved than the one of F105 (73.5% versus 91.8%). (B) The variable light chain of 1F7 derives from a different germline gene (IGKV1D-33*01) than the other CD4bs antibody light chain fragments.