A Human Antibody to the CD4 Binding Site of gp120 Capable of Highly Potent but Sporadic Cross Clade Neutralization of Primary HIV-1
Figure 7
Neutralization (IC50s) of HIV-1 JR-CSF and JR-FL N-glycosylation mutants using 1F7 and other CD4bs mAbs.
Neutralization assay was performed in the TZM-bl assay format. Boxes are color-coded as follows: white, median potency >50 µg/mL; green, median potency between 20 and 50 µg/mL; yellow, median potency between 2 and 20 µg/mL; orange, median potency between 0.2 and 2 µg/mL; red, median potency <0.2 µg/mL.