Cyclosporin A Inhibits Rotavirus Replication and Restores Interferon-Beta Signaling Pathway In Vitro and In Vivo
Figure 5
Effect of CsA on SA11 rotavirus-infected neonatal mouse model.
Neonatal mice were inoculated with SA11 rotavirus, and mice developed diarrhea during the 18–24 h of experimental observation. The mice scored for diarrhea were randomly divided into 3 groups (30 mice each group). Mice were subjected to PBS, Ribavirin (5 mg/kg/d), or CsA (2.5 mg/kg/d) treatments by oral gavages. (A) Healing time. (B) Rotavirus-antigen clearance rate (%) in stool. Data shown are expressed as mean ± standard deviation of triplicate cultures, and are representative of 3 experiments (*P<0.05, **P<0.01).