A Yeast-Based Chemical Screen Identifies a PDE Inhibitor That Elevates Steroidogenesis in Mouse Leydig Cells via PDE8 and PDE4 Inhibition
Figure 3
IC50 values for BC8-15 and related compounds.
The structures of BC8-15 and two structurally-related derivatives are shown. The IC50 values of each compound were determined by in vitro PDE assays (see Material and Methods). The values represent mean IC50± SD determined from three independent experiments.