Genome Sequencing and Analysis of BCG Vaccine Strains
Figure 3
Genealogy of Bacillus Calmete-Guérin (BCG) vaccine strains and Mycobacterium tuberculosis strains.
The genealogy of BCG strains based on Keller et al. 15, displays a series of genomic alterations including regions of deletion (RDs; squares bordered with a solid line) and single nucleotide proteins (grey squares bordered with a dotted line). The blue squares in the figure represent published RDs, while the white squares represent newly identified RDs. The brown ovals are assumed to be ancestor strains without genome sequences. The solid arrows represent the process of strains living in the lab under human manipulation conditions, while the dotted arrows represent the process of strains living in their natural environments. The BCG and M. tuberculosis strains are divided by dotted lines in the figure.