Analysis of Trafficking, Stability and Function of Human Connexin 26 Gap Junction Channels with Deafness-Causing Mutations in the Fourth Transmembrane Helix
Figure 10
L205V mutant cannot be rescued by the WT.
(A) Homomeric oligomers of L205V are unstable. Similar to the I203T mutant shown in Fig. 9, (B) this mutant did not display stable hemichannels or channels when I203T monomers where mixed with the WT monomers in a 2:1 ratio of WT:L205V-V5-His6.