Diverse Secreted Effectors Are Required for Salmonella Persistence in a Mouse Infection Model
Figure 3
CIqPCR analysis in 129SvJ mice for effectors dependent on SPI-2.
20 mice were infected with mutant strains as well as the wild-type control. Spleens from 5 mice were extracted at days 2, 6, 9, and 14 post-infection. The persistence levels of the various strains were determined using qPCR. The average CIqPCR values are depicted here and the error bars indicate the standard deviation. Strains with CIqPCR values greater than 1 demonstrate that these strains outcompeted the wild-type strains and strains with CIqPCR values less than 1 indicate that they were outcompeted by the wild-type strain. Each panel from A to W represents CIqPCR data for a mutant strain obtained at 2, 6, 9, and 14 days post-infection.