Hepatitis C Virus Induced miR200c Down Modulates FAP-1, a Negative Regulator of Src Signaling and Promotes Hepatic Fibrosis
Figure 2
Biological networks modulated by the differentially expressed miRNA in chronic HCV.
The biological networks modulated by differentially expressed miRNA following HCV infection was analyzed using the Genego software. Genego analysis of the networks identified: a) regulation of the phospholipase C pathway (miR200c, miR20b, and miR31 through cSrc); b) response to endogenous stimulus of growth factors and hormones (miR141, miR107 and miR200c through PPAR-α and ERK); and c) regulation of cellular proliferation (miR20b, miR10b, and miR141 through p21) as the major biological pathways that are impacted.