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Transcriptional Blood Signatures Distinguish Pulmonary Tuberculosis, Pulmonary Sarcoidosis, Pneumonias and Lung Cancers

Figure 6

Unlike TB and pneumonia, successful treatment of sarcoidosis was associated with increased transcriptional activity.

(A) Modular analysis. Gene expression levels of all transcripts that were significantly detected compared to background hybridisation in at least 10% of samples (p<0.01) were compared between the healthy controls and each of the following the patient groups: pre-treatment pneumonia, post-treatment pneumonia patients and pre-treatment sarcoidosis, inadequate treatment response sarcoidosis and good-treatment response sarcoidosis patients. A red dot indicates significant over-abundance of transcripts and a blue dot indicates under-abundance (p<0.05). The colour intensity correlates to the percentage of genes in that module that are significantly differentially expressed. MDTH demonstrates the quantification of transcriptional change after treatment in the 1446-transcripts relative to controls. The mean, SEM and p-values are displayed (ANOVA with Tukey’s multiple comparison test). (B) Pneumonia patients. (D) Sarcoidosis patients. (C) TB patients from the Bloom et al study carried out in South Africa, the controls in this study were participants with latent TB.

Figure 6

doi: https://doi.org/10.1371/journal.pone.0070630.g006