Pharmacological Induction of Transforming Growth Factor-Beta1 in Rat Models Enhances Radiation Injury in the Intestine and the Heart
Figure 3
Effects of radiation and xaliproden on left ventricular gene expression of TGF-β1 and TGF-β pathway mediators.
Xaliproden caused a significant increase in left ventricular mRNA of TGF-β1 (A), endoglin (B), PAI-1 (C), and both radiation and xaliproden caused a downregulation of Id-1 mRNA when compared to vehicle-treated rats (D). Average ± SEM, n = 3. #Significant difference with sham-irradiated animals (p<0.05), *Significant difference with vehicle-treated animals (p<0.05).