Protection of Radiation-Induced Damage to the Hematopoietic System, Small Intestine and Salivary Glands in Rats by JNJ7777120 Compound, a Histamine H4 Ligand
Figure 2
Effect of JNJ7777120 on radiation-induced damage on salivary function.
(A) Mean salivary secretion in irradiated and non-irradiated, untreated and JNJ7777120-treated rats. Error bars represent the means ± SEM (**P<0.01, ***P<0.001, vs. Untreated, ###P<0.001 vs. Untreated-5Gy). (B) ¶SMG’s percentage of body weight (SMG weights were divided by total body weight in grams and multiplied by 100). Data represent the means ± SEM (*P<0.05 vs. Untreated; #P<0.05 vs. Untreated-5Gy). Inset: JNJ7777120 compound significantly preserves SMG mass. (C) H4R immunoreactivity. H4R was detected in some (a) acini and also (b) excretory ducts. (D) AQP5 immunoreactivity. AQP5 was detected almost exclusively in acini in (a) untreated, (b) JNJ777120-treated and (d) treated and irradiated rats. (c) Reduce AQP5 immunoreactivity and altered distribution in SMG of irradiated rats. Pictures were taken at 630x-fold magnification. Scale bar= 20 µm.