Abnormal Expression of Cerebrospinal Fluid Cation Chloride Cotransporters in Patients with Rett Syndrome
Figure 2
Cation Chloride Cotransporters ratio.
(A) Immunoblot analysis of NKCC1 and KCC2. (B) Scatterplot of the relationship between Cotrasporters ratio (KCC2/NKCC1) and age for Rett Patients and Controls. Lines show a LOWESS smooth (locally-weighted polynomial regression - nonparametric smooth) suggesting a discrepant cotransporter ratio between Patients and Controls supported by the respective ANCOVA (F (1, 70) = 30.08, p = .001, ηp2 = .29). (C) Boxplot of Cotransporters ratio (KCC2/NKCC1) for Rett Patients and Controls (males and females). *p = 0.001.