Sphingosine Kinase Activity Is Not Required for Tumor Cell Viability
Figure 7
Phamacokinetic and pharmacodynamic properties of compound A in vivo.
Compound A was administered to athymic nude mice by oral gavage. At the indicated time points, blood was collected and plasma levels of compound A (left panel) as well as S1P (right panel) were determined. Compound levels were corrected for binding to murine plasma, and concentrations of free compound A is depicted in this graph. *P<0.05 compared to vehicle.