Oncogenic Actions of the Nuclear Receptor Corepressor (NCOR1) in a Mouse Model of Thyroid Cancer
Figure 4
Expression of NCOR1ΔID promotes apoptosis of thyroid tumor cells of ThrbPV/PVNcor1ΔID/ΔID mice.
(A) Nuclear protein extracts were prepared from thyroid tumors of ThrbPV/PVNcor1+/+ (lanes 1 and 2) or ThrbPV/PVNcor1ΔID/ΔID (lanes 3 and 4) mice. Shown are Western blot analyses of BAX (panel a), PUMA (panel b), cleaved caspase 3 (panel c), PARP and cleaved PARP (panel d), and actin loading control (panel e). (B) Quantitation of the band intensities shown in (A). *p<0.05 Protein abundance of BAX and PUMA (panel a), cleaved caspase 3 and cleaved PARP (panel b) was significantly higher and total PARP (panel b) was lower in the thyroids of ThrbPV/PVNcor1ΔID/ΔID mice.