The Time Course of Gene Expression during Reactive Gliosis in the Optic Nerve
Figure 3
The loss of ganglion cells in the retina.
A. Ganglion cell soma degeneration was estimated by counting the neurons in the mid-peripheral retina with the nuclear dye To-Pro1. B. The crushed eyes had a clear reduction 1 week after crush and reached a plateau (about 40% neuron loss in ganglion cell layer) by 3 weeks. The contralateral eyes were not different from the naïve controls at any time point. (* Two-tailed paired t-test p<0.05).