Autophagic Killing Effects against Mycobacterium tuberculosis by Alveolar Macrophages from Young and Aged Rhesus Macaques
Figure 4
Bactericidal capacity of resting alveolar macrophages.
Alveolar macrophages were infected at an MOI of 5∶1 with M. tuberculosis CDC1551. Bacterial survival was followed over seven days by harvesting the infected monolayers at the indicated timepoints and plating serial dilutions. The assay was performed in triplicate and the average and standard deviation for each time point are shown for each RM sample. The reference number for each RM is noted in the legend. Bacterial survival in alveolar macrophages from adult (left) and aged (right) RM is shown. There was no significant difference in mycobacterial survival between groups at t = 7d (Student's t-test, p = 0.0693).