Ablation of Keratan Sulfate Accelerates Early Phase Pathogenesis of ALS
Figure 2
KS expression began before body weight loss.
(A) The lysates of the SOD1G93A lumbar spinal cords at 6, 12, 18, and 24 weeks of age were subjected to immunoblotting using the anti-KS antibody 5D4. β-actin was used as the internal loading control. A faint expression of KS was detected at 12 weeks. (B) The SOD1G93A lumber spinal cord section at 12 weeks was stained by anti-KS antibody. KS immunoreactivity was observed in the ventral horn. Bar, 200 µm.