Activity Determinants of Helical Antimicrobial Peptides: A Large-Scale Computational Study
Figure 6
The correlation between transfer energy to pores and deviation of ln(MIC*AS) and from predictions of the ‘carpet’ model.
cyl: the pore is a cylindrical pore with R = 13Å. tor: the pore is a toroidal pore with R = 13Å, K = 15Å, h = 0.6. The anionic fractions of the lipids are 10% and 30% respectively for ln(MIC*As) and . The red lines are the best fitted lines. For
, [L] is assumed to be 20 µM and f* is assumed to be 0.2.