Characterization Analysis of Schistosoma japonicum Plasma Membrane Repair Relative Gene Myoferlin
Figure 5
TEM observation of ultrastructural alterations in S. japonicum caused by PZQ.
These micrographs provide a visual sample of the comparative damage induced by PZQ in the control group (A), 36 h after treatment with 200 mg/kg PZQ (B), 4 h after treatment with 40 mg/kg PZQ (C, D), and 36 h after treatment with 40 mg/kg PZQ (E, F). The outer plasma membrane was smooth and integral and musculature was regular (arrow in A) in the control group. The tegumental matrix and parenchymal tissues lost their definition and became indistinct and there was focal or extensive lysis of muscle bundles and parenchymal tissues, which resulted in vacuole formation (arrow in B). Plates C showed vacuole formation in the matrix ((large arrow in C) and in parenchymal tissues (small arrow in C). The underlying muscle bundles were swollen (small arrow in D). The surface returned to its normal morphological appearance and the large vacuoles were decreased and turned substantial (Plates E), but the muscle bundles were still swollen (arrow in F).