Combining Antiangiogenic Therapy with Adoptive Cell Immunotherapy Exerts Better Antitumor Effects in Non-Small Cell Lung Cancer Models
Figure 3
Rh-endostatin treated tumors show increased Ktrans value for Gd-DTPA and delayed Evans blue extravasation.
DCE-MRI and intravital microscopy were performed to test tumor vascular permeability to small molecules and macromolecules, respectively. A, representative images of DCE-MRI with Gd-DTPA well infiltrating in the A549 tumor. B, the columns represent mean ± SE of Ktrans for A549 tumors in control group and rh-endostatin treated group at day3, 6 and 9. C, the columns represent mean ± SE of Evans blue extravasation time in control group and rh-endostatin treated group at day 3, 6 and 9. Columns, mean; Bars, SE; *p<0.05 indicating statistical significance. Results shown are representative of 3 independent experiments.