Sonic Hedgehog Signaling Pathway Supports Cancer Cell Growth during Cancer Radiotherapy
Figure 3
Effects of SHH signaling antagonists on dying cell induced tumor cell repopulation.
A. GDC0449, a preclinical SHH pathway inhibitor, inhibits Panc1Fluc cell growth induced by dying Panc1 cell in a dose-dependent manner. Top: signal intensity analysis from bioluminescence image; Bottom: representative bioluminescence images; scale bar represents 1 cm. *represents P<0.05. B. Gant61 inhibits Panc1Fluc cells growth induced by dying Panc1 cells in a dose-dependent manner. Top: signal intensity analysis from bioluminescence image; Bottom: representative bioluminescence images; scale bar represents 1 cm. **represents P<0.01. C. Cyclopamin inhibits HT29Fluc cell growth induced by dying HT29 cells in a dose-dependent manner. Top: signal intensity analysis from bioluminescence image; Bottom: representative bioluminescence images; scale bar represents 1 cm. *represents P<0.05, **represents P<0.01. D. Gant61 inhibits HT29Fluc cell growth induced by dying HT29 cells in a dose-dependent manner. Top: signal intensity analysis from bioluminescence image; Bottom: representative bioluminescence images; scale bar represents 1 cm. **represents P<0.01. E. GDC0449 inhibits HT29 Fluc cell growth induced by dying HT29 cells in a dose-dependent manner. Top: signal intensity analysis from bioluminescence image; Bottom: representative bioluminescence images; scale bar represents 1 cm.