Three-Dimensional Collagen I Promotes Gemcitabine Resistance In Vitro in Pancreatic Cancer Cells through HMGA2-Dependent Histone Acetyltransferase Expression
Figure 6
Regulation of gemcitabine resistance by HMGA2 and HATs.
Previously, we had published that the collagen microenvironment induced HMGA2 expression [Dangi-Garimella S et al, [6]]. We now demonstrate that PDAC cells in the collagen microenvironment induce HMGA2-dependent HAT expression and histone H3 acetylation, suggesting that the collagen microenvironment promotes euchromatin formation. This signaling pathway allows PDAC cells to resist the effects of gemcitabine in the collagen microenvironment.