Circulating Mitochondrial DNA as Biomarker Linking Environmental Chemical Exposure to Early Preclinical Lesions Elevation of mtDNA in Human Serum after Exposure to Carcinogenic Halo-Alkane-Based Pesticides
Figure 1
Exposure assessment in subjects with presumed intoxication with halo-alkane-based pesticides (fumigants).
A. Formation of hemoglobin adducts: MEV (upper panel), HEV (middle panel), CEV (lower panel) in smoking (s) and non-smoking subgroups (ns). The data are shown as box plots indicating the minimum, the 25-percentile, the 75-percentile values; the medians are shown as a cross line. Blue boxes show non-smoking subgroups (ns) while the grey ones represent smoking subgroups (s); for both subgroups (s, ns) the empty boxes show data for the non-exposed controls (Co), the boxes with the dashed lines show exposed individuals (P). B. Retrospective exposure estimated for all tested subjects with presumed intoxication to methyl- or ethyl halide pesticides. As described in the methods, the exposure was weighted from the human biomonitoring data and expert valuation of the job history and clinical data. The lines show calculated exposure values to methyl bromide (red) or ethylene dichloride/dichloromethane (blue). The concentrations are shown in ppm (mL/m3).