Misexpression of Pknox2 in Mouse Limb Bud Mesenchyme Perturbs Zeugopod Development and Deltoid Crest Formation
Figure 3
Alterations in Hox gene expression in the limb of Prx1-Pknox2 embryos.
A-F’: Expression of Hoxd9 (A, A’), Hoxa10 (B, B’), Hoxd10 (C, C’), Hoxa11 (D, D’), Hoxd11 (E, E’) and Hoxd13 (F, F’) in WT (A-F) and Prx1-Pknox2 embryos (A’-F’) in E11.5 forelimbs. The Hoxa10, Hoxd10 and Hoxd11 expression domains are anteriorly shifted (double arrows in B-C’, E, E’), whereas the Hoxa11 expression domain is shortened in the central zeugopod region (double arrows in D, D’) (n = 3). The limb is oriented so that the anterior is on the top and the posterior is on the bottom.