Anxiolytic-Like Effects of Antisauvagine-30 in Mice Are Not Mediated by CRF2 Receptors
Figure 1
Effects of antisauvagine-30, astressin2-B and CRF2 genotype on shock-induced freezing.
The data are expressed as M ± SEM. Antisauvagine-30 (i.c.v., 3 nmol) significantly and equally reduced the duration of shock-induced freezing in both wildtype and CRF2 knockout mice. In contrast, the same dose of astressin2B, a selective CRF2 antagonist, and CRF2 null genotype did not alter shock-induced freezing (n = 6–9/group). *p<0.05, differs from vehicle and astressin2-B-treated mice (Fisher's protected least significant difference test).