Increased Cortical Activity in Binge Drinkers during Working Memory Task: A Preliminary Assessment through a Functional Magnetic Resonance Imaging Study
Figure 4
Part A. Higher correlation between working memory-related BOLD activity in DMPFC and ADO values in binge drinkers than control subjects (p uncorr <.001; cluster extent ≥100 voxels). The more binge drinkers ingested alcohol doses per occasion, the higher the BOLD response (reflected by level of activation change) in DMPFC was in N2 compared to N0, whereas it was not the case for controls. Part B. Higher correlation between working memory-related BOLD activity in cerebello-thalamo-insular regions and DOW values in binge drinkers than control subjects (p uncorr <.001; cluster extent ≥100 voxels). The higher the number of drinking occasion per week in binge drinkers, the higher the BOLD response in these regions in N2 as compared to N0, whereas it was not the case for controls.