Recent Adaptive Events in Human Brain Revealed by Meta-Analysis of Positively Selected Genes
Figure 2
Positively-selected genes of Group 3 and 4 but not Group 1 were highly expressed in brain.
(A) Enrichment pattern of positively-selected genes in nine human tissues based on mRNA-SEQ dataset. Blue, red, green and purple bars indicate positively-selected genes in Groups 1, 2, 3 and 4, respectively. The sign of y-axis represents the under-representation (−) or enrichment (+). The bars with significant corrected P-value are marked by asterisks. (B) Brain tissue also shows significant absence (corrected P-value <0.05) for Group 1 and enrichment (corrected P-value <0.05) for Group 3 and 4 based on cDNA microarray dataset. The FDR corrected P-value is labeled on each bar. (C) Using the stringent subset of positively selected genes supported by two or more studies in each group (red square; n = 85, 79, 11 and 89, respectively), the pattern is even stronger than using all positively selected genes (blue diamond; n = 1141, 1033, 1058 and 1660, respectively), based on mRNA-SEQ dataset. (D) Fifteen of 17 CNS regions show significant absence (corrected P-value <0.05) for Group 1 genes and enrichment (corrected P-value <0.05) for Group 3 and 4 genes. The two exceptional tissues are cerebellum and cerebellar peduncles.