Hydroxysteroid Sulfotransferase SULT2B1b Promotes Hepatocellular Carcinoma Cells Proliferation In Vitro and In Vivo
Figure 5
Knock-down of SULT2B1b suppressed tumorigenesis in vivo.
1.5×106 NC-GFP-LV or SULT2B1-RNAi-LV Hepa1-6 cells were injected subcutaneously into the subaxillary space of each nude mouse. (A) The growth curve of xenografts. (B) Representative fluorescence images of xenografts. (C) Images of dissected tumors. (D) The weights of dissected tumors. (E) Western-blot analysis of the protein levels of the cell growth-associated genes, BCL2, MYC, cyclinD1, and cyclinB1 in dissected tumors. The quantification of protein levels of the above genes is shown to the right. *represents P<0.05 vs. NC-GFP-LV group.