MACC1 Down-Regulation Inhibits Proliferation and Tumourigenicity of Nasopharyngeal Carcinoma Cells through Akt/β-Catenin Signaling Pathway
Figure 1
MACC1 protein expression in NPC cell lines (C666-1, HNE1, SUNE-1, CNE1 and CNE2) and normal nasopharyngeal cell (NP69) by western blot analysis(A); MACC1 mRNA expression in NPC cell lines and normal nasopharyngeal cell (NP69) by real-time PCR analysis (B); MACC1, β-catenin and Met expression in NPC and chronic inflammation of the nasopharynx (CIN) tissues by immunohistochemistry staining(C-D).
AEG-1, β-catenin and Met expression was shown in CIN (a, b, c) and NPC with clinical stage I (d, e, f), II (g, h, i), III (j, k, l), and IV(m, n, o). Immunohistochemistry staining ×200(C); MACC1 and β-catenin expression was higher in NPC than that in chronic inflammation of the nasopharynx, respectively *p<0.001. There was no significant difference between Met expression in NPC and chronic inflammation of the nasopharynx (D).