Optimisation of Embryonic and Larval ECG Measurement in Zebrafish for Quantifying the Effect of QT Prolonging Drugs
Figure 1
Detection of electrocardiographic signal.
A) Depiction of an electrocardiogram and associated components, created using Adobe Photoshop CS6, B) 2 second section of a raw ECG recording from a larval zebrafish (3 dpf) without digital filtering, C) digitally filtered version of the ECG recording using low pass filtering to reduce background noise and produce a waveform suitable for analysis, D) analysed trace showing waveform reproducibility and stability during the recording period, with each line representing one cardiac cycle. The dark line in the middle represents the mean of all cycles from a 1 minute record.