Macrophages as IL-25/IL-33-Responsive Cells Play an Important Role in the Induction of Type 2 Immunity
Figure 6
Adoptive transfer of IL-33-activated macrophages promoted protective immunity against H. bakeri (Hb) infection.
A–C, Numbers of adult worms in the lumen of small intestine in mice receiving BMDM (A), PECs (B), or CD11b MicroBead-enriched PECs (C). D, E, Enhanced type 2 immunity in mice that received IL-33-activated CD11b MicroBead-enriched PECs (IL-33-Macs). Intestinal smooth muscle function (D) and in situ IL-13 production in the small intestine and spleen (E) were shown. Data shown in bar and line graphs are the mean ± s.e.m, and are representative of two independent experiments (n = 3–6 mice per group, *p<0.05 vs respective vehicle-Macs, t test; p = 0.02 was generated from two-way ANOVA with repeated measures between the two curves). ND, not detected.