Molecular Study of Dietary Heptadecane for the Anti-Inflammatory Modulation of NF-kB in the Aged Kidney
Figure 6
Heptadecane attenuated NF-kB-responsive COX-2 and iNOS via NIK/IKK and MAPKs.
YPEN-1 cells were grown to 80% confluent in 100 mm dishes in DMEM. Cells were pre-treated (1 hr) with heptadecane (20 µM) and inhibitors and then stimulated with 10 µM t-BHP. After stimulation with t-BHP in the absence (−) or presence (+) of heptadecane and each kinase inhibitor, COX-2 and iNOS gene expressions were determined in cell extracts.