A Biophysical Model of Endocannabinoid-Mediated Short Term Depression in Hippocampal Inhibition
Figure 4
Panel A: Simulated peak calcium concentrations in response to various depolarisation durations (0.5–5 sec) with Protocol 2, plotted against the respective DSI measure for each depolarisation. Panel B: Experimental results from slices [40] showing the fitted Hill function (in blue) of the relation between calcium concentration and DSI. The light blue area indicates the range of maximum and minimum values for the fitted Hill function. The results from the model simulations obtained with Protocol 3 - case 1 are shown in black circles and for Protocol 3 - case 2 in red circles.