Cholesterol Biosynthesis and Homeostasis in Regulation of the Cell Cycle
Figure 3
Cell size and cellular lipid content vary with cell cycle progression.
(A) Cell size increased linearly as cells progressed from G1 to G2 via S phase of cell cycle. Total cellular phospholipid and cholesterol contents in G1, S and G2 phases of cell cycle are shown in panels (B) and (C), respectively. Phospholipid content showed an excellent correlation with the cell size in respective phases (shown as an inset of panel (B)). Values are normalized to that of G1 phase. Data represent means ± SE of at least four independent experiments. See Materials and Methods for more details.