Qualification of Standard Membrane-Feeding Assay with Plasmodium falciparum Malaria and Potential Improvements for Future Assays
Figure 3
Relationship between 4B7 concentration and PIm.
Various concentrations of 4B7 mAb were tested in the qualification experiments (Feed 7–9). For these data the first COM negative control is matched with the first COM of the 4B7 mAb at each concentration, the second with the second, etc. The square root of 4B7 concentration is shown on the x-axis, and the ratio of mean oocyst (mean of oocysts in control divided by mean of oocysts in test) is plotted on a log scale (shown on left side of y-axis, the associated PIm value is shown on the right side of the y-axis). Points with the same symbol use the same control, and points with the same color are from the same feed. Dotted line represents the best-fit line.