Biodistribution and Elimination Study of Fluorine-18 Labeled Nε-Carboxymethyl-Lysine following Intragastric and Intravenous Administration
Figure 3
19F-CML/18F-CML identification result.
A. HPLC analysis result of the standard cold product 19F-CML. B. LC/MS analysis result of 19F-CML. C. HPLC analysis of the 18F-CML with radioactivity detection showing radiochemical a purity of 18F-CML >95%. The chromatograms of the purified 18F-CML were characterized using a radioactivity detector, and 19F-CML was characterized using a UV detector (254 nm) under the same analytical HPLC conditions. The resulting 18F-CML was determined to have a radiochemical purity of 96% and the same retention time as 19F-CML. D. Radio HPLC analysis at 40 min after injection of 18F-CML. No metabolic products were observed in the urine.