Serotonin (5-HT) Affects Expression of Liver Metabolic Enzymes and Mammary Gland Glucose Transporters during the Transition from Pregnancy to Lactation
Figure 2
Effects of feeding diets enriched in 5-HTP and L-TRP on serum 5-HT, insulin and glucose in rats.
Serum 5-HT concentrations on d20 of gestation (d20-G), d1 and d9 of lactation (d1-L, d9-L) (A). 5-HT protein concentration and mRNA expression of TPH1 in the mammary gland (B-D) and liver (E-G) on d9-L. Serum insulin (H) and plasma glucose (I) concentrations on d20-G and d9-L, milk glucose concentrations at d1, d5 and d9 of lactation (J), in dams fed CON, 5-HTP, and L-TRP diets, and milk lactose concentrations at d1, d5, and d9 of lactation (I), in dams fed CON, 5-HTP, and L-TRP diets. Data are represented as mean ± SEM. Single asterisk (*) indicate statistical significance at P<0.05, two asterisks (**) at P<0.01, three (***) at P<0.001 and four (****) at P<0.0001.