Noninvasive and Targeted Gene Delivery into the Brain Using Microbubble-Facilitated Focused Ultrasound
Figure 2
Correlation between MRI and GFP expressions.
(a) T1-weighted MR images showing BBB disruption by different acoustic pressures (bar = 1 mm) and (b) respective GFP expression by immunofluorescence (bar = 200 µm). (c) Increase in GFP signal intensity at different acoustic powers. (d) Correlation of the change in MR signal intensity with the increase in AAV2-GFP expression (r2 = 0.687). In (a), circles in dashed lines represent the FUS exposure area, and the rectangular regions represents the zoomed immunofluorescence regions.