High Temporal Resolution Parametric MRI Monitoring of the Initial Ischemia/Reperfusion Phase in Experimental Acute Kidney Injury
Figure 5
Ischemia reperfusion results derived from the standardized segmentation model of the kidney: Plots of T2* (mean ±SEM averaged over six animals) versus time for the ROIs in the cortex (C1, C2, C3; top row), in the outer medulla (O1, O2, O3; middle row), and in the inner medulla (I1, I2, I3; bottom row).
Ischemia (shaded in gray) led to an immediate and significant T2* decrease in all kidney ROIs (p≤0.01 in C1, p≤0.001 in all other ROIs). Clear differences between cortex, outer medulla and inner medulla were observed. At the end of the reperfusion period T2* was close to baseline (dashed line) in the cortex (p>0.2), below baseline in the outer medulla (p≤0.05 (C1), p≤0.001 (C2), p≤0.01 (C3)), and above baseline in the inner medulla (non-significant). The three ROIs within each kidney regions showed very similar but not identical trends.