miR-126&126* Restored Expressions Play a Tumor Suppressor Role by Directly Regulating ADAM9 and MMP7 in Melanoma
Figure 4
Effects of miR-126&126* overexpression in in vivo xenograft models. A)
In vivo tumor growth at different time points deriving from vector- or miR-126&126*-infected metastatic melanoma cell lines s.c. injected into athymic nude mice. Representative nodules are shown as an insert. B) Representative flow cytometer results of doxycycline-dependent induction of the RFP reporter in cells deriving from dissociated tumor nodules. C) Total number (left) and representative pictures (right) of lung and liver macroscopic metastases obtained by intravenous injection of the A375M cell lines. Columns, mean±SD of two independent experiments; **, P<0.001; *, P<0.05.