Contrasting Properties of α7-Selective Orthosteric and Allosteric Agonists Examined on Native Nicotinic Acetylcholine Receptors
Figure 4
Positive allosteric modulation of α7 nAChRs by TQS examined by patch-clamp in rat primary hippocampal cells.
A) Representative recordings showing responses to the application of compound B (1 µM; Left; black bar) and of TQS (10 µM; grey bar) pre-applied for 5 s and then co-applied with compound B (1 µM; Right; black bar). B) Co-application of compound B (1 µM; black bar) with TQS (10 µM; grey bar) results in a two-component response.