Sodium Valproate Alleviates Neurodegeneration in SCA3/MJD via Suppressing Apoptosis and Rescuing the Hypoacetylation Levels of Histone H3 and H4
Figure 6
Valproic acid ameliorates climbing ability of SCA3 Drosophila model.
Light-induced positive geotactic response (time to reach to 17.5 cm high) was investigated. Wild-type and MJDtr-Q78-expressing flies were tested following VPA treated for 5 (A) or 15 days (B) after flies reached adulthood, # represents compared to wild-type flies without treating with VPA, P<0.05; * represents compared to the same genotype flies without treating with VPA, P<0.05. ** Represents compared to the same genotype flies without treating with VPA, P<0.01. Error bars represent S.E.M (n = 200). Although wild-type flies showed no differences in behavior, all MJDtr-Q78-expressing flies showed a significant dose-dependent increase in performance, p<0.05. When VPA treated at doses from 0 mM to 1 mM, and the increase was obvious in elav-MJDtr-Q78 (m) than other genotypes. When VPA treated at a dose of 1.5 mM or higher, the climbing ability of all MJDtr-Q78-expressing flies were gradually reduced, even so, when VPA treated at doses of 2.5 mM, all MJDtr-Q78-expressing flies performed better than non-treated flies.