Pax6 Interactions with Chromatin and Identification of Its Novel Direct Target Genes in Lens and Forebrain
Figure 8
Diagrammatic summary of novel functions of Pax6 during lens development.
The connections between genes regulated by Pax6 in lens placode were identified via Ingenuity Pathway Analysis (IPA) (Ingenuity Systems, Mountain View, CA). Expression of Stat3 is reduced in the Pax6 mutated E9.5 embryonic tissues. The Tnf promoter region is occupied by Pax6 in lens chromatin.